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KDR

kinase insert domain receptor (a type III receptor tyrosine kinase)

Synonyms:
CD309, FLK1, VEGFR, VEGFR2
Species:
UniProtKB ID:
Gene ID:
  • Human(3791) Summary: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
  • Mouse(16542) kinase insert domain protein receptor
  • Rat(25589) kinase insert domain receptor
  • chicken(395323) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Zebrafish(554230) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Thale Cress(839585) basic helix-loop-helix protein KIDARI
  • dog(482154) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Goat(100860836) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • cow(407170) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Horse(100033959) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • domestic cat(101090260) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Domestic Rabbit(100008607) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • sheep(443087) vascular endothelial growth factor receptor-2
  • naked mole-rat(101726029) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • domestic guinea pig(100726761) kinase insert domain receptor (a type III receptor tyrosine kinase)

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ELISA

Product Number
Description
Species
Human VEGF R2 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human
Mouse Kdr / Vascular Endothelial Growth Factor Receptor 2 ELISA Kit, ,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-KDR (AB2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-KDR (AB1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-KDR (Ab-951) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-Vascular Endothelial Growth Factor Receptor 2 antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse
Application
flow cytometry
immunohistochemistry

neutralization

western blot
Anti-VEGFR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Axitinib, ≥98% (HPLC),
Species
human
PD 173074, ≥96% (HPLC), powder,
Species
mouse, human
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human
SU 5416, ≥98% (HPLC),
Species
human, mouse
Sunitinib malate, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
KDR Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant, human KDR amino acids 790-end,
for use in Kinase Assays.
,
Species
human
VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Kdr,
Species
mouse
MISSION® esiRNA, targeting human KDR,
Species
human