MilliporeSigma

MPZL2

myelin protein zero-like 2

Synonyms:
EVA, EVA1
Species:
UniProtKB ID:
Gene ID:
  • Human(10205) Summary: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14012) myelin protein zero-like 2
  • Rat(300679) myelin protein zero-like 2
  • chicken(419779) myelin protein zero-like 2
  • dog(489384) myelin protein zero-like 2
  • domestic cat(101089039) myelin protein zero-like 2
  • naked mole-rat(101711086) myelin protein zero-like 2
  • domestic guinea pig(100728058) myelin protein zero-like 2
  • sheep(101122302) myelin protein zero-like 2
  • cow(540423) myelin protein zero-like 2

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-MPZL2 antibody produced in mouse, clone 2E10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
Anti-MPZL2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MPZL2,
Species
human