MilliporeSigma

NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Synonyms:
GCCR, GCR, GR, GRL
Species:
UniProtKB ID:
Gene ID:
  • Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
  • Mouse(14815) nuclear receptor subfamily 3, group C, member 1
  • Rat(24413) nuclear receptor subfamily 3, group C, member 1
  • domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
  • cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

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Small Molecule - Activator

Product Number
Description
Species
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Species
human
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Species
human, rat
Mifepristone, ≥98%,
Species
human, mouse, rat

Small Molecule - Agonist

Product Number
Description
Species
Hydrocortisone, European Pharmacopoeia (EP) Reference Standard,
Species
human
Dexamethasone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Prednisone, ≥98%,
Species
human
Hydrocortisone, British Pharmacopoeia (BP) Assay Standard,
Species
human
Hydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Clobetasol propionate, analytical standard,
Species
human, rat
Hydrocortisone 21-acetate, ≥98% (HPLC),
Species
human
Hydrocortisone 21-acetate, meets USP testing specifications,
Species
human
6α-Methylprednisolone, ≥98%,
Species
human, rat
Mifepristone, United States Pharmacopeia (USP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NR3C1 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Anti-Glucocorticoid Receptor Antibody, clone 2K3E8, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunoprecipitation (IP)
western blot
Anti-Phospho-NR3C1-S211 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-NR3C1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, pig
Application
immunohistochemistry
western blot
Anti-phospho Glucocorticoid Receptor (Ser134) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
canine, feline, horse, human, rat, sheep
Application
western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Dexamethasone, VETRANAL®, analytical standard,
Species
human
Medroxyprogesterone 17-acetate, ≥97% (HPLC),
Species
human, rat
Dexamethasone, tested according to Ph. Eur.,
Species
mouse, rat, human
Dexamethasone, ≥98% (HPLC), powder,
Species
mouse, rat, human
Dexamethasone, powder, BioReagent, suitable for cell culture, ≥97%,
Species
mouse, rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Nr3c1,
Species
mouse
MISSION® esiRNA, targeting human NR3C1,
Species
human