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PDE3A

phosphodiesterase 3A, cGMP-inhibited

Synonyms:
CGI-PDE, CGI-PDE A, CGI-PDE-A
Species:
UniProtKB ID:
Gene ID:
  • Human(5139) Summary: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
  • Mouse(54611) phosphodiesterase 3A, cGMP inhibited
  • Rat(50678) phosphodiesterase 3A, cGMP inhibited
  • domestic cat(101088586) phosphodiesterase 3A, cGMP-inhibited
  • naked mole-rat(101704787) phosphodiesterase 3A, cGMP-inhibited
  • Domestic Rabbit(100009330) phosphodiesterase 3A, cGMP-inhibited
  • Horse(100034086) phosphodiesterase 3A, cGMP-inhibited
  • sheep(101115870) phosphodiesterase 3A, cGMP-inhibited
  • Zebrafish(567051) phosphodiesterase 3A, cGMP-inhibited
  • cow(536636) phosphodiesterase 3A, cGMP-inhibited
  • chicken(418185) phosphodiesterase 3A, cGMP-inhibited
  • domestic guinea pig(100302667) phosphodiesterase 3A, cGMP inhibited

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PDE3A antibody produced in mouse, clone 5C12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-PDE3A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PDE3A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Cilostazol, United States Pharmacopeia (USP) Reference Standard,
Species
human
Cilostazol, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Amrinone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Milrinone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Enoximone, solid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Pde3a,
Species
mouse
MISSION® esiRNA, targeting human PDE3A,
Species
human