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PRKAA1

protein kinase, AMP-activated, alpha 1 catalytic subunit

Synonyms:
AMPK, AMPKa1
Species:
UniProtKB ID:
Gene ID:
  • Human(5562) Summary: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(105787) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Rat(65248) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Horse(100009710) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • sheep(100294665) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • dog(479351) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • domestic guinea pig(100714483) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Zebrafish(100001198) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • chicken(427185) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • cow(540404) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • naked mole-rat(101722998) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • sheep(101103425) protein kinase, AMP-activated, alpha 1 catalytic subunit
  • domestic cat(101095885) protein kinase, AMP-activated, alpha 1 catalytic subunit

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-AMPK alpha Antibody, clone 2D22, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-phospho-AMPK α (Thr172) Antibody, Upstate®, from rabbit,
Species Reactivity
human, rat
Application
western blot
Anti-Phospho-PRKAA1-T183/PRKAA2-T172 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Phospho-PRKAA1-T183/PRKAA2-T172 antibody produced in rabbit, ,
Species Reactivity
human, rat
Application
western blot
Anti-Phospho-PRKAA1-T183/PRKAA2-T172 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot

Proteins

Product Number
Description
Species
AMPK (α1/β1/γ1), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
AMPK (α1/β1/γ3), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
AMPK (α1/β2/γ1), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PRKAA1,
Species
human
MISSION® esiRNA, targeting mouse Prkaa1,
Species
mouse