MilliporeSigma

PTK2

protein tyrosine kinase 2

Synonyms:
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
Species:
UniProtKB ID:
Gene ID:
  • Human(5747) Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
  • Mouse(14083) PTK2 protein tyrosine kinase 2
  • Rat(25614) protein tyrosine kinase 2
  • Horse(100058245) PTK2 protein tyrosine kinase 2
  • cow(506270) PTK2 protein tyrosine kinase 2
  • domestic cat(101095952) PTK2 protein tyrosine kinase 2
  • domestic guinea pig(100725669) protein tyrosine kinase 2
  • dog(475108) PTK2 protein tyrosine kinase 2
  • chicken(396416) PTK2 protein tyrosine kinase 2
  • naked mole-rat(101711587) protein tyrosine kinase 2
  • sheep(101120842) PTK2 protein tyrosine kinase 2

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Phosphotyrosine PTK2 / Focal Adhesion Kinase 1 ELISA Kit, ,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PTK2 antibody produced in mouse, clone 1C1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-PTK2 (Ab-576/577) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-phospho-PTK2 (pTyr861) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-phospho-FAK (pTyr861) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
ANTI-PTK2 antibody produced in mouse, clone 1D7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

Proteins

Product Number
Description
Species
FAK Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, human FAK, amino acids 411-686, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PTK2,
Species
human