MilliporeSigma

PTPN11

protein tyrosine phosphatase, non-receptor type 11

Synonyms:
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species:
UniProtKB ID:
Gene ID:
  • Human(5781) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • Mouse(19247) protein tyrosine phosphatase, non-receptor type 11
  • Rat(25622) protein tyrosine phosphatase, non-receptor type 11
  • sheep(101114308) protein tyrosine phosphatase, non-receptor type 11
  • naked mole-rat(101701336) protein tyrosine phosphatase, non-receptor type 11
  • dog(477488) protein tyrosine phosphatase, non-receptor type 11
  • domestic cat(101085500) protein tyrosine phosphatase, non-receptor type 11
  • chicken(395815) protein tyrosine phosphatase, non-receptor type 11
  • Horse(100056857) protein tyrosine phosphatase, non-receptor type 11
  • cow(533590) protein tyrosine phosphatase, non-receptor type 11
  • domestic guinea pig(100732797) protein tyrosine phosphatase, non-receptor type 11

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PTPN11 (AB2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-PTPN11 (AB1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-SHP2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti- pTyr580 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
Anti-phospho-SHP-2 (pTyr542) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Proteins

Product Number
Description
Species
SHP-2 Active human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PTPN11,
Species
human
MISSION® esiRNA, targeting mouse Ptpn11,
Species
mouse