MilliporeSigma

SLC6A4

solute carrier family 6 (neurotransmitter transporter), member 4

Synonyms:
5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Species:
UniProtKB ID:
Gene ID:
  • Human(6532) Summary: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
  • Mouse(15567) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • Rat(25553) solute carrier family 6 (neurotransmitter transporter), member 4
  • domestic guinea pig(100135619) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • naked mole-rat(101705584) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • Domestic Rabbit(100340600) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • Domestic Rabbit(100351801) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • dog(491184) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • domestic cat(101091163) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • Horse(100053721) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • cow(282365) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • chicken(404747) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Antagonist

Product Number
Description
Species
Diphenyl-4-pyridylmethane, 99%,
Species
rat
N-Ethylmaleimide, BioXtra, ≥98% (HPLC),
Species
human
N-Ethylmaleimide, BioUltra, ≥99.0% (HPLC),
Species
human
N-Ethylmaleimide, purum p.a., ≥99.0% (HPLC),
Species
human
4-Benzylpyridine, 98%,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SLC6A4 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, human, mouse, rat
Application
ELISA
flow cytometry

immunofluorescence
Anti-SLC6A4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-SLC6A4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Anti-Serotonin (5-HT) Transporter (602-622) Rabbit pAb, lyophilized, Calbiochem®,
Species Reactivity
mouse, rat
Application
Monoclonal Anti-SLC6A4 antibody produced in mouse, clone 2A9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA

Small Molecule - Inhibitor

Product Number
Description
Species
Fluoxetine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Fluoxetine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Paroxetine maleate salt, ≥98% (HPLC), solid,
Species
human
Fluvoxamine maleate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Escitalopram oxalate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
Cocaine free base, ,
Species
mouse, rat, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human SLC6A4,
Species
human