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TK2

thymidine kinase 2, mitochondrial

Synonyms:
MTDPS2, MTTK
Species:
UniProtKB ID:
Gene ID:
  • Human(7084) Summary: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
  • Mouse(57813) thymidine kinase 2, mitochondrial
  • Rat(291824) thymidine kinase 2, mitochondrial
  • chicken(427551) thymidine kinase 2, mitochondrial
  • Zebrafish(437016) thymidine kinase 2, mitochondrial
  • naked mole-rat(101704299) thymidine kinase 2, mitochondrial
  • domestic guinea pig(100727406) thymidine kinase 2, mitochondrial
  • sheep(101103665) thymidine kinase 2, mitochondrial
  • cow(615457) thymidine kinase 2, mitochondrial
  • Horse(100065312) thymidine kinase 2, mitochondrial
  • domestic cat(101085008) thymidine kinase 2, mitochondrial
  • dog(611387) thymidine kinase 2, mitochondrial

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TK2 (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-TK2 (N-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
Anti-TK2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
3′-Deoxy-3′-fluorothymidine, 97%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human TK2,
Species
human
MISSION® esiRNA, targeting mouse Tk2,
Species
mouse