MilliporeSigma

UGT1A4

UDP glucuronosyltransferase 1 family, polypeptide A4

Synonyms:
HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D
Species:
UniProtKB ID:
Gene ID:
  • Human(54657) Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]
  • Zebrafish(100384901) UDP glucuronosyltransferase 1 family, polypeptide A4
  • sheep(100534646) UDP glucuronosyltransferase 1 family, polypeptide A4

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-UGT1A4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Diosgenin, ≥93%,
Species
human
5α-Androstane, ,
Species
human
Diphenylamine, puriss. p.a., redox indicator, ACS reagent, reag. Ph. Eur., ≥98% (GC),
Species
human
4-Nitrophenol, spectrophotometric grade,
Species
human
Eugenol, ReagentPlus®, 99%,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human UGT1A4,
Species
human