MilliporeSigma

WRAP53

WD repeat containing, antisense to TP53

Synonyms:
DKCB3, TCAB1, WDR79
Species:
UniProtKB ID:
Gene ID:
  • Human(55135) Summary: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
  • Mouse(216853) WD repeat containing, antisense to Trp53
  • Rat(287432) WD repeat containing, antisense to TP53
  • Domestic Rabbit(100343593) WD repeat containing, antisense to TP53
  • domestic guinea pig(100733673) WD repeat containing, antisense to TP53
  • dog(607892) WD repeat containing, antisense to TP53
  • naked mole-rat(101702587) WD repeat containing, antisense to TP53
  • domestic cat(101099509) WD repeat containing, antisense to TP53
  • cow(509631) WD repeat containing, antisense to TP53
  • sheep(101103738) WD repeat containing, antisense to TP53
  • Zebrafish(321796) WD repeat containing, antisense to TP53

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-WRAP53 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-WRAP53 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-WRAP53 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human WRAP53,
Species
human