774405

(S)-2-Aminobutane-1,4-dithiol hydrochloride

99% (titration)

• Synonym(s): (S)-2-Aminobutane-1,4-dithiol hydrochloride, (2S)-2-Amino-1,4-dimercaptobutane hydrochloride, DTBA, Dithiobutylamine
• Empirical Formula (Hill Notation): C₄H₁₁NS₂ · HCl
• CAS Number: 1363376-98-0
• Molecular Weight: 173.73
• MDL number: MFCD23704430
• UNSPSC Code: 12352200
• PubChem Substance ID: 329767683
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 99% (titration)
• form: solid
• reaction suitability: reagent type: reductant
• mp: 210-225 °C
• storage temp.: 2-8°C
• SMILES string: Cl.N[C@H](CS)CCS
• InChI: 1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1
• InChI key: HWWPXJZINVJNBM-WCCKRBBISA-N

Description

Application

(S)-2-Aminobutane-1,4-dithiol hydrochloride (DTBA), also known as dithiobutylamine, is a biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.

Dithiobutylamine or DTBA is a new biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable