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Sigma-Aldrich

(±)-3-Chloro-1,2-propanediol

98%

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Synonym(s):
α-Chlorohydrin, α-Glycerol chlorohydrin, α-Monochlorohydrin, 3-MCPD
Linear Formula:
ClCH2CH(OH)CH2OH
CAS Number:
Molecular Weight:
110.54
Beilstein:
635684
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

vapor pressure

0.04 mmHg ( 25 °C)

Quality Level

Assay

98%

refractive index

n20/D 1.480 (lit.)

bp

213 °C (lit.)

solubility

H2O: soluble
alcohol: soluble
diethyl ether: soluble

density

1.322 g/mL at 25 °C (lit.)

SMILES string

OCC(O)CCl

InChI

1S/C3H7ClO2/c4-1-3(6)2-5/h3,5-6H,1-2H2

InChI key

SSZWWUDQMAHNAQ-UHFFFAOYSA-N

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This Item
29208732406184489
1-Chloro-2-propanol 70%

Sigma-Aldrich

292087

1-Chloro-2-propanol

refractive index

n20/D 1.480 (lit.)

refractive index

n20/D 1.439 (lit.)

refractive index

n20/D 1.480 (lit.)

refractive index

n20/D 1.483 (lit.)

bp

213 °C (lit.)

bp

126-127 °C (lit.)

bp

213 °C (lit.)

bp

174.3 °C (lit.)

solubility

H2O: soluble, alcohol: soluble, diethyl ether: soluble

solubility

-

solubility

-

solubility

water: soluble 10 part, alcohol: miscible, diethyl ether: miscible

density

1.322 g/mL at 25 °C (lit.)

density

1.111 g/mL at 25 °C (lit.)

density

1.322 g/mL at 25 °C (lit.)

density

1.363 g/mL at 20 °C, 1.351 g/mL at 25 °C (lit.)

vapor pressure

0.04 mmHg ( 25 °C)

vapor pressure

-

vapor pressure

0.04 mmHg ( 25 °C)

vapor pressure

-

General description

3-Chloro-1,2-propanediol undergoes enantioselective transformation to (R)-3-chloro-1,2-propanediol by the cell extract of Corynebacterium sp. strain N-1074 . It is a contaminant found in food in free (diol) form as well as in an esterified (with fatty acids) form.

Application

(±)-3-Chloro-1,2-propanediol may be used in manufacture of dye intermediates.

Biochem/physiol Actions

3-Chloro-1,2-propanediol is a potent rodent chemosterilant.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Muta. 2 - Repr. 1B

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Slide 1 of 2

1 of 2

W Seefelder et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 391-400 (2008-03-19)
3-Mono-chloropropane-1,2-diol (3-MCPD) is a contaminant that occurs in food in its free (diol) form as well as in an esterified (with fatty acids) form. Using a simple intestinal model, it was demonstrated that 3-MCPD monoesters and 3-MCPD diesters are accepted
Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats.
E Samojlik et al.
Biology of reproduction, 2(2), 299-304 (1970-04-01)
T Nakamura et al.
Journal of bacteriology, 174(23), 7613-7619 (1992-12-01)
During the course of the transformation of 1,3-dichloro-2-propanol (DCP) into (R)-3-chloro-1,2-propanediol [(R)-MCP] with the cell extract of Corynebacterium sp. strain N-1074, epichlorohydrin (ECH) was transiently formed. The cell extract was fractionated into two DCP-dechlorinating activities (fractions Ia and Ib) and
Brian D Craft et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(3), 354-361 (2011-12-16)
Recently, organic and inorganic chlorinated compounds were detected in crude and commercially refined palm oils. Further, the predominant formation mechanism of monochloropropanediol (MCPD) diesters at high temperatures (>170-180°C) was revealed. The present study involved the development and comparison of solutions
Z Zelinková et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(6), 669-676 (2008-05-20)
A series of twelve breast milk samples were analysed by gas chromatography-mass spectrometry (GC/MS) operated in selected ion monitoring mode for 3-chloropropane-1,2-diol (3-MCPD). Whilst none of the samples contained 3-MCPD above the limit of detection of 3 microg kg(-1) milk

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