394238

Pyrrolidine

≥99.5%, purified by redistillation

• Synonym(s): Tetrahydropyrrole, Tetramethyleneimine
• Empirical Formula (Hill Notation): C₄H₉N
• CAS Number: 123-75-1
• Molecular Weight: 71.12
• Beilstein/REAXYS Number: 102395
• EC Number: 204-648-7
• MDL number: MFCD00005249
• UNSPSC Code: 12352100
• PubChem Substance ID: 24864581
• NACRES: NA.22

Properties

• vapor density: 2.45 (vs air)
• Quality Level: 200
• vapor pressure: 128 mmHg ( 39 °C); 49 mmHg ( 20 °C)
• assay: ≥99.5%
• form: liquid
• autoignition temp.: 653 °F
• purified by: redistillation
• expl. lim.: 10.6 %
• refractive index: n20/D 1.443 (lit.)
• solubility: water: miscible
• density: 0.852 g/mL at 25 °C (lit.)
• SMILES string: C1CCNC1
• InChI: 1S/C4H9N/c1-2-4-5-3-1/h5H,1-4H2
• InChI key: RWRDLPDLKQPQOW-UHFFFAOYSA-N

Description

General description

Pyrrolidine is a five membered cyclic amine. It is a nitrogen heterocycle that forms the nucleus of various bioactive molecules. It can be synthesized by reacting 1,4-diaminobutanes with acids. It behaves as a strong base in employed in certain homogeneous nonaqueous reactions. Its crystalline structure has been investigated. Its reaction on the Ge(100)-2×1 surface and Si(100)-2×1 surface has been investigated. Pyrrolidine has been found to be one of the component of volatile amine fraction in the brewing process. A study on the kinetics of pyrrolidinolysis of phthalimide (PTH) shows second- and third-order terms in the rate law. Biodegradation of pyrrolidine by Mycobacterium strains has been studied.

Application

Pyrrolidine may be used in the following studies:

• Synthesis of pyrrolidine derivatives of pyrimidine.
• As a catalyst in the selective monoallylation of allylic alcohols.
• To capture carbondioxide in a bubble column reactor using pyrrolidine aqueous solutions by gas–liquid absorption.

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H302 + H332,H314
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 37.4 °F - closed cup
• flash_point_c: 3 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter