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764760

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 2,000, PLGA average Mn 11,500

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Synonym(s):
PEG-PLGA, mPEG-b-PLGA
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23

form

pellets

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 2,000
PLGA average Mn 11,500
average Mn 13,500 (total)

degradation timeframe

1-4 weeks

transition temp

Tm 298-303 °C
Tg 40 °C (PDLLA block)
Tg 6 °C (PEG block)

PDI

≤2.0

storage temp.

2-8°C

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This Item
764752764825913138
mol wt

PEG average Mn 2,000, PLGA average Mn 11,500, average Mn 13,500 (total)

mol wt

PEG average Mn 5,000, PLGA Mn 55,000, average Mn 60,000 (total)

mol wt

PEG Mn 2,000, PLGA Mn 4,500, average Mn 6,500 (total)

mol wt

PEG average Mn 2,000, PLGA average Mn 10,000 (by NMR)

transition temp

Tm 298-303 °C, Tg 40 °C (PDLLA block), Tg 6 °C (PEG block)

transition temp

Tg 10 °C(lit.), Tm 254-259 °C

transition temp

Tm 241-246 °C

transition temp

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 65:35

feed ratio

lactide:glycolide 50:50

General description

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.

Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Features and Benefits

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Che-Ming Jack Hu et al.
International journal of nanomedicine, 13, 8579-8593 (2018-12-28)
Influenza virus infections are a major public health concern worldwide. Conventional treatments against the disease are designed to target viral proteins. However, the emergence of viral variants carrying drug-resistant mutations can outpace the development of pathogen-targeting antivirals. Diphyllin and bafilomycin
Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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