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Sigma-Aldrich

Poly(lactide-co-caprolactone)-block-poly(ethylene glycol)-block-poly(lactide-co-caprolactone)

average Mn 5700-4600-5700

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Synonym(s):
PLCL-PEG-PLCL
NACRES:
NA.23

form

pellets

feed ratio

lactide 50:50

mol wt

PEG average Mn 5,000 (DCM, PEO)
PLCL average Mn 5,700
average Mn (1,000-10,000-1,000)

degradation timeframe

1-2 months

transition temp

Tm 34-41 °C

PDI

<1.2
<1.3 (typical PEG; overall PDI <1.8 (THF, PEO))

storage temp.

2-8°C

Related Categories

General description

It belongs to the family of synthetic biodegradable polymers. It exihibits excellent tissue compatibility. PLCL-PEG-PLCL polymers are studies extensively for its drug delivery capability (both hydrophobic and hydrophilic drugs).

Application

1. Drug delivery
2. Ligament-bone interface mimicking

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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Biodegradable polyester based nanoparticle formation
Material Matters, 7(3) (2012)
Bret D Ulery et al.
Journal of polymer science. Part B, Polymer physics, 49(12), 832-864 (2011-07-20)
Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant advantage of being able to be broken down and removed after they have served their function. Applications are

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