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790257

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

average Mn 6,000-12,000

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Synonym(s):
Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)
Linear Formula:
[C2H2N2O2R[(C3H4O2)x(C2H2O2)y]m[C2H4O]lO[(C3H4O2)x(C2H2O2)y]m]n

form

paste

feed ratio

(Prepolymer (PLGA-PEG-PLGA): Diisocyanate :: 1:0.8)
PEG:DL-lactide:glycolide 19:65:16
lactide:glycolide 1:0.8

mol wt

PEG average Mn 400
average Mn 6,000-12,000

degradation timeframe

<4 months

viscosity

8.79 Pa.s(100 °C) (at Angular Frequency (1/s) 5.46 Anton-Parr Rhometer)
466 Pa.s(50 °C) (at Angular Frequency (1/s) 1.33, Anton-Parr Rhometer)

transition temp

Tg <0 °C

PDI

<2.0

storage temp.

2-8°C

SMILES string

CC(N[R]NC(OC(C)C(OCC(OCCOC(C(C)OC(COC)=O)=O)=O)=O)=O)=O.CC(N[R]NC(OCCCOC)=O)=O

Related Categories

Application

  • This poly(ether ester urethane) based on PLGA-PEG-PLGA triblock copolymers linked with a diisocyanate is a biodegradable; resorbable gel former for use in drug delivery systems.
  • This polymer doesn′t rely on temperature or pH to induce gelation and therefore form more consistent and faster-setting drug delivery depots.
  • Through combination of various gel formers and/or diluents; drug release profiles may be modulated to exhibit fast burst release through extended (up to 1 month) zero-order release profile.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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