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Sigma-Aldrich

2′-Deoxyguanosine 5′-monophosphate disodium salt hydrate

≥98%

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Synonym(s):
2′-Deoxy-5′-guanylic acid disodium salt, 5′-dGMP disodium salt
Empirical Formula (Hill Notation):
C10H12N5Na2O7P · xH2O
CAS Number:
Molecular Weight:
391.18 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

≥98%

form

solid

impurities

≤4% ethanol

mp

>245 °C (dec.) (lit.)

SMILES string

[Na+].[Na+].[H]O[H].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])([O-])=O)O3)C(=O)N1

InChI

1S/C10H14N5O7P.2Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;;1H2/q;2*+1;/p-2/t4-,5+,6+;;;/m0.../s1

InChI key

HQSJCEYJAGVPJG-BIHLCPNHSA-L

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This Item
648604G8377900384
form

solid

form

solid

form

powder

form

liquid

assay

≥98%

assay

≥95% (CP)

assay

≥99%

assay

≥95% (CP)

mp

>245 °C (dec.) (lit.)

mp

-

mp

-

mp

-

impurities

≤4% ethanol

impurities

-

impurities

-

impurities

-

Application

Reactant involved in:
  • Analysis of self-assembling in solution and nucleation / growth of G-qudruplexes
  • Nucleophilic trapping
  • Reductive alkylation

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Mahmoud Kandeel et al.
Nucleic acids symposium series (2004), (53)(53), 39-40 (2009-09-15)
In Plasmodium falciparum, deoxyguanylate was found to be a substrate for several DNA metabolizing enzymes. Guanylate kinase utilizes dGMP with very low specificity, which is estimated to be the lowest among well-known prokaryotic and eukaryotic enzymes. Furthermore, thymidylate kinase, which
Mariana P Serrano et al.
Physical chemistry chemical physics : PCCP, 14(33), 11657-11665 (2012-07-25)
UV-A radiation (320-400 nm) induces damage to the DNA molecule and its components through photosensitized reactions. Biopterin (Bip) and its photoproducts 6-formylpterin (Fop) and 6-carboxypterin (Cap) accumulate in the skin of human beings suffering from vitiligo, a depigmentation disorder where
Mingfeng Li et al.
PloS one, 8(1), e54420-e54420 (2013-02-01)
Free extracellular DNA provides nutrition to bacteria and promotes bacterial evolution by inducing excessive mutagenesis of the genome. To understand the influence of extracellular DNA fragments on D. radiodurans, we investigated cell growth and survival after extracellular DNA or dNMPs
Yancheng Liu et al.
Photochemistry and photobiology, 88(3), 639-644 (2012-02-11)
Laser flash photolysis studies have been carried out to investigate the reactions of ciprofloxacin (CPX) with 2'-deoxyguanosine-5'-monophosphate (dGMP), N, N, N', N'-tetramethyl-p-phenylenediamine (TMPD) and ferulic acid (FCA) in neutral aqueous solutions, respectively. CPX triplet state ((3)CPX*) can be quenched by
Aya Kato et al.
Parasitology international, 61(3), 501-503 (2012-03-20)
During the course of our research into new anti-malaria drugs, Plasmodium falciparum thymidylate kinase (PfTMK) has emerged as an important drug target because of its unique substrate specificity. Compared with human thymidylate kinase (HsTMK), PfTMK shows broader substrate specificity, which

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