MilliporeSigma
All Photos(2)

Documents

900657

Sigma-Aldrich

Methoxy poly(ethylene glycol)-b-poly(D,L-lactide)

2k-5k

Sign Into View Organizational & Contract Pricing

Synonym(s):
mPEG-b-PLA, mPEG-PLA
Linear Formula:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
NACRES:
NA.23

Quality Level

form

powder or chunks

mol wt

PDLLA average Mn ~5,000
PEG average Mn ~2,000

storage temp.

2-8°C

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(D,L-lactide) (PLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Zahra Daman et al.
Pharmaceutical research, 32(11), 3756-3767 (2015-08-01)
Resistance to gemcitabine in pancreatic cancer (PC) may account for the failure of conventional treatments. Recently, salinomycin (SAL) has been identified as selective inhibitor of cancer stem cells (CSCs). In our study, we aimed to deliver SAL to gemcitabine-resistant PC
Ho-Chul Shin et al.
Journal of controlled release : official journal of the Controlled Release Society, 140(3), 294-300 (2009-05-05)
Current clinical and preclinical anticancer formulations are limited by their use of toxic excipients and stability issues upon combining different drug formulations. We have found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically
Yuan Zhang et al.
Pharmaceutical research, 28(5), 1167-1178 (2011-02-23)
Somatostatin analogue octreotide (OCT)-modified PEG-b-PLA micelles were constructed to bind to somatostatin receptors (SSTRs) overexpressed on tumor cells for enhanced intracellular drug delivery and improved therapeutic efficacy for malignant tumors. Copolymers conjugated with octreotide (OCT-PEG₆₀₀₀-b-PLA₅₀₀₀) were synthesized. The fluorescent probe
Yiguang Wang et al.
Pharmaceutical research, 27(9), 1861-1868 (2010-06-19)
To develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent. CA4-loaded micelles were prepared from poly (ethylene glycol)-b-poly (d, l-lactide) copolymers. RGD peptides that target integrins alphavbeta3 and alphavbeta5, markers of angiogenic

Articles

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service