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909149

Sigma-Aldrich

Poly(ethylene glycol) diamine

average Mn 400

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Synonym(s):
Poly(ethylene glycol) bis(amine), O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)
Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
MDL number:

form

viscous liquid

mol wt

average Mn 400 (by NMR)
average Mn 400

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

color

colorless to pale yellow

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

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This Item
7524441450114508
vibrant-m

909149

Poly(ethylene glycol) diamine

vibrant-m

752444

Poly(ethylene glycol) diamine

vibrant-m

14501

Poly(ethylene glycol) bis(amine)

vibrant-m

14508

Poly(ethylene glycol) bis(amine)

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

mol wt

average Mn 400 (by NMR)

mol wt

average Mn 6,000

mol wt

Mw 2,000

mol wt

Mw 10,000

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

-

Ω-end

amine

Ω-end

amine

Ω-end

amine

Ω-end

amine

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Application

PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. Polymer for preparing enzyme conjugates soluble in organic solvents; promising drug carrier.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells.
Bhattacharya R, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 3, 224-238 (2007)
Facile Synthesis of a Degradable Poly(ethylene glycol) Platform with Tunable Acid Sensitivity at Physiologically Relevant pH.
Li Z C, et al.
Macromolecules, 51, 6571-6579 (2018)
Rigidity of Two-Component Hydrogels Prepared from Alginate and Poly(ethylene glycol)-Diamines.
Eiselt P, et al.
Macromolecules, 32 (17), 5561-5566 (1999)

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