MilliporeSigma
All Photos(1)

926000

Sigma-Aldrich

TissueFab® bioink kit

(Gel)ma Laminin -Vis/405 nm, low endotoxin

All Photos(1)

form

viscous liquid (gel)

size

10 mL

impurities

<5 cfu/mL Bioburden
<50 EU/mL Endotoxin

color

pale yellow to colorless

pH

6.5-7.5

viscosity

3-30 cP

application(s)

3D bioprinting

storage temp.

−20°C

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

1 of 4

This Item
926019927074927066
Sigma-Aldrich

Sigma-Aldrich

926000

TissueFab® bioink kit

Sigma-Aldrich

Sigma-Aldrich

926019

TissueFab® bioink kit

Sigma-Aldrich

Sigma-Aldrich

927074

TissueFab® bioink kit

Sigma-Aldrich

Sigma-Aldrich

927066

TissueFab® bioink kit

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

form

viscous liquid (gel)

form

viscous liquid (gel)

form

(Solid chunks, fibers or powder)

form

viscous liquid (gel)

size

10 mL

size

10 mL

size

-

size

-

impurities

<5 cfu/mL Bioburden

impurities

<5 cfu/mL Bioburden, <50 EU/mL Endotoxin

impurities

<10 CFU/g Bioburden (Fungal) , <10 CFU/g Bioburden (Total Aerobic), <125 EU/g Endotoxin

impurities

<5 CFU/g Bioberden: Aerobic, <5 CFU/g Bioberden: Fungal, <50 EU/mL Endotoxin

color

pale yellow to colorless

color

pale yellow to colorless

color

, Pale white to colorless

color

pale yellow to colorless

pH

6.5-7.5

pH

6.5-7.5

pH

-

pH

6.5-7.5

General description

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. Laminin is an extracellular matrix multidomain trimeric glycoprotein and is the main non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. Laminin is composed of both A, B1 and B2 chains, which are connected by many disulfide bonds. This laminin product was isolated from mouse Engelbreth-Holm-Swarm tumor. Laminin proteins are integral components of structural scaffolding in animal tissues. They associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystroglycan glycoprotein complexes and Lutheran blood group glycoproteins.

Application

The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation Gelatin methacrylate based bioinks have been used to bioprint osteogenic [1], chondrogenic [2-3], hepatic [4-6], adipogenic [7], vasculogenic [8], epithelial [6], endothelial [9-10], cardiac valve [11], skin [12], tumor [10] and other tissues and constructs. Laminin has active domains for collagen binding, cell adhesion, heparin binding, and neurite outgrowth fragment. Laminin has been used in tissue engineering applications for corneal [13], organoids[14] and neurodegenerative diseases [15-16].

Features and Benefits

In addition to fast gelation, the methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.

Legal Information

TISSUEFAB is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service