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Sigma-Aldrich

Linear polyethylenimine-block-poly(ethylene glycol)

PEG average Mn 5,000, PEI average Mn 5,000

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Synonym(s):
PEG-b-PEI, PEG-PEI, Poly(ethylene glycol)-block-polyethylenimine
Linear Formula:
CH3(C2H4O)n(C2H5N)mOH

form

powder and chunks

Quality Level

mol wt

PEG Mn 5,000 Da
PEG average Mn 5,000
PEI Mn 5,000 Da
PEI average Mn 5,000

color

white to pale yellow

storage temp.

2-8°C

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Application

Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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