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A59654

Sigma-Aldrich

5-Aminoindole

97%

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Synonym(s):
5-Indolamine, NSC 61452
Empirical Formula (Hill Notation):
C8H8N2
CAS Number:
Molecular Weight:
132.16
Beilstein:
112348
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

form

crystals

mp

131-133 °C (dec.) (lit.)

SMILES string

Nc1ccc2[nH]ccc2c1

InChI

1S/C8H8N2/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H,9H2

InChI key

ZCBIFHNDZBSCEP-UHFFFAOYSA-N

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This Item
445355630721130877
5-Aminoindole 97%

Sigma-Aldrich

A59654

5-Aminoindole

(S)-(+)-1-Aminoindan 97%

Sigma-Aldrich

445355

(S)-(+)-1-Aminoindan

6-Aminoindole 97%

Sigma-Aldrich

630721

6-Aminoindole

5-Aminoindan 95%

Sigma-Aldrich

130877

5-Aminoindan

form

crystals

form

liquid

form

solid

form

solid

mp

131-133 °C (dec.) (lit.)

mp

-

mp

75-79 °C

mp

34-36 °C (lit.)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

Application

Reactant for preparation of:
  • Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
  • Cytotoxic and antimitotic agents
  • Insulin-like growth factor 1 receptor inhibitors
  • Antitumoral agents
  • Factor Xa inhibitor
  • Potential antivascular agents
  • Gli1-mediated transcription in the Hedgehog pathway
  • Inhibitors of receptor tyrosine kinase with antiangiogenic effects
  • PKCθ inhibitors
  • HIV protease inhibitors

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Dermal

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Michael Jakun Koo et al.
Biochemical and biophysical research communications, 464(3), 875-880 (2015-07-19)
Cellular metabolism can impact cell life or death outcomes. While metabolic dysfunction has been linked to cell death, the mechanisms by which metabolic dysfunction regulates the cell death mode called necroptosis remain unclear. Our study demonstrates that mitochondrial oxidative phosphorylation

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