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C91492

Sigma-Aldrich

Cyanogen bromide

reagent grade, 97%

Synonym(s):

Bromine cyanide

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About This Item

Linear Formula:
BrCN
CAS Number:
Molecular Weight:
105.92
Beilstein/REAXYS Number:
1697296
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

grade

reagent grade

Quality Level

vapor density

3.65 (vs air)

vapor pressure

100 mmHg ( 22.6 °C)

assay

97%

form

crystals

bp

61-62 °C (lit.)

mp

50-53 °C (lit.)

storage temp.

2-8°C

SMILES string

BrC#N

InChI

1S/CBrN/c2-1-3

InChI key

ATDGTVJJHBUTRL-UHFFFAOYSA-N

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General description

Cyanogen bromide (CNBr) is a halogen halide. Its utility as a condensing agent during chemical ligation of oligodeoxyribonucleotides has been reported. Its threshold photoelectron (TPE) spectrum has been recorded under high resolution. The cryopolymerization of CNBr on irradiation has been investigated.

Application

Cyanogen bromide may be used:
  • To activate polysaccharides for coupling with erythrocytes.
  • As an oxidizing agent in urine thaimine assay.
  • In the preparation of 2-amino-5-(2′-thienyl)-1,3,4-oxadiazole.
For peptide cleavage and use in protein immobilization procedures. Reaction with C60Ph5Cl produces a novel phenylated isoquinolino[3′,4′:1,2][60]fullerene.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B

supp_hazards

wgk_germany

WGK 3

flash_point_f

closed cup

flash_point_c

closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges


Certificates of Analysis (COA)

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Applied Biochemistry and Biotechnology, 44, 135-135 (1994)
Org. Mass Spectrom., 28, 1395-1395 (1993)
Abdul-Sada, A.K. et al.
Chemical Communications (Cambridge, England), 307-307 (1998)
N I Sokolova et al.
FEBS letters, 232(1), 153-155 (1988-05-09)
Cyanogen bromide was found to condense oligodeoxyribonucleotides on a complementary template in aqueous solution. Optimum conditions for this vigorous and effective reaction were developed. CNBr proved to be useful for incorporation of phosphoramidate or pyrophosphate internucleotide bonds in DNA duplexes.
Threshold photoelectron spectroscopy of cyanogen bromide.
Yencha AJ, et al.
Chemical Physics Letters, 392(1), 202-208 (2004)

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