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QBD10503

Sigma-Aldrich

Azido-dPEG®8-NHS ester

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Synonym(s):
2,5-Dioxo-1-pyrrolidinyl 3-[(23-azido-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]propanoate
Empirical Formula (Hill Notation):
C23H40N4O12
CAS Number:
Molecular Weight:
564.58
MDL number:
PubChem Substance ID:
NACRES:
NA.22

assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry

functional group

NHS ester
azide

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

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This Item
QBD10501QBD10523QBD10567
Azido-dPEG®8-NHS ester

QBD10503

Azido-dPEG®8-NHS ester

Azido-dPEG®4-NHS ester

QBD10501

Azido-dPEG®4-NHS ester

Azido-dPEG®7-amine

QBD10523

Azido-dPEG®7-amine

Azido-dPEG ®4-TFP ester

QBD10567

Azido-dPEG ®4-TFP ester

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

functional group

NHS ester, azide

functional group

NHS ester, azide

functional group

amine, azide

functional group

azide, ester

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent
reaction type: click chemistry

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent
reaction type: click chemistry

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent
reaction type: click chemistry

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent
reaction type: click chemistry

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Features and Benefits

The azido-dPEG®8-NHS ester contains an azide function on one end of a single molecular weight dPEG® spacer(32.2 Å) and a reactive group (NHS ester) on the other end of the spacer. The dPEG® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. N-hydroxysuccinimide (NHS) ester readily react with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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