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D-920

Supelco

N-Desmethyltrimipramine maleate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

N-Desmethyltrimipramine maleate solution

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About This Item

Empirical Formula (Hill Notation):
C19H24N2 · C4H4O4
CAS Number:
67341-71-3
Molecular Weight:
396.48
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

General description

N-Desmethyltrimipramine is a primary blood metabolite of trimipramine. Trimipramine is a tricyclic antidepressant prescribed for treatment of depression, insomnia, and chronic pain or as an adjunctive therapy for alcohol or opioid withdrawal. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for pain prescription monitoring, urine drug testing, clinical toxicology, and forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Degen et al.
Medizinische Klinik (Munich, Germany : 1983), 88(3), 129-133 (1993-03-15)
The pharmacokinetics of the antidepressants amitriptyline oxide and trimipramine and their major metabolites amitriptyline, nor-triptyline and desmethyltrimipramine, were studied in twelve healthy male subjects (aged from 22 to 62 years) and twelve patients (aged from 25 to 73 years) with
J Liu et al.
Journal of chromatography. B, Biomedical sciences and applications, 700(1-2), 175-182 (1997-12-09)
A sensitive and stereospecific method for the quantitation of trimipramine enantiomers in human serum was developed. The assay involves the use of a novel mixed-mode disc solid-phase extraction for serum sample clean-up prior to HPLC analysis and is also free
A A Gulaid et al.
Journal of chromatography, 566(1), 228-233 (1991-05-03)
Trimipramine is a tricyclic antidepressant drug often assayed by gas chromatographic or gas chromatographic-mass spectrometry techniques. A high-performance liquid chromatographic method with electrochemical detection is described for the assay of trimipramine and its major metabolites, monodesmethyltrimipramine and 2-hydroxytrimipramine, in plasma.
In vitro metabolism of desmethyltrimipramine to yield hydroxylamino compound.
S Ozkirimli et al.
Acta pharmaceutica Suecica, 23(1), 57-59 (1986-01-01)
A D Fraser et al.
Journal of analytical toxicology, 11(4), 168-170 (1987-07-01)
A fatality following ingestion of the tricyclic antidepressant trimipramine (Surmontil) is described. Quantitation was performed by high-performance liquid chromatography. Trimipramine and desmethyltrimipramine concentrations were 4.8 and 2.1 mg/L, respectively, in postmortem blood. The concentration of trimipramine, desmethyltrimipramine, and their respective
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