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M-120

Supelco

Morphine-6-β-D-glucuronide-D3 solution

100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C23H24NO9D3
CAS Number:
Molecular Weight:
464.48
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

100 μg/mL in methanol: water (1:1)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

[2H]C([2H])([2H])N1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c35

InChI

1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1/i1D3

InChI key

GNJCUHZOSOYIEC-YTLCJKNCSA-N

General description

Morphine-6ß-D-glucuronide is a primary plasma and urinary metabolite of the opiate analgesic morphine. Sold under trade names including MS Contin®, Kadian®, Oramorph®, and Roxanol for pain relief, morphine is also a commonly abused recreational drug. This stable-labeled internal standard is suitable for quantitation of morphine levels in urine, serum, or plasma by LC/MS or GC/MS for pain prescription monitoring, urine drug testing, clinical toxicology, or forensic analysis.

Application


  • Comprehensive analysis of analgesics and metabolites: A sophisticated LC-MS/MS method was developed for the simultaneous quantification of analgesics, including Morphine-6-β-D-glucuronide, and their metabolites in human plasma. This technique is pivotal for pharmacokinetic studies in clinical settings, demonstrating the critical role of high-purity analytical standards in medical research (Jutras et al., 2020).

  • Enhanced detection in opioid metabolite research: The study utilized advanced LC-MS/MS techniques to assess the presence of opiates and their metabolites, such as Morphine-6-β-D-glucuronide, in urine following cold syrup consumption. This research underscores the utility of stable isotope-labeled compounds in enhancing the sensitivity and accuracy of drug testing protocols (Yen et al., 2020).

  • Capillary electrophoresis-mass spectrometry applications: Capillary electrophoresis-mass spectrometry was employed to determine morphine and its isobaric glucuronide metabolites, illustrating a vital analytical approach for precise measurements in biochemical assays, especially in studying complex drug metabolism pathways (Isbell et al., 2015).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Kadian is a registered trademark of Actavis Elizabeth LLC
MS Contin is a registered trademark of Purdue Frederick Company
Oramorph is a registered trademark of AAIPharma, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

75.2 °F - closed cup

flash_point_c

24 °C - closed cup


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