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M-132

Supelco

MSTFA Reagent

ampule of 10 × 1.2 mL, analytical standard, Cerilliant®

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Synonym(s):
N-Methyl-N-(trimethylsilyl)trifluoroacetamide, N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA
Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
Molecular Weight:
199.25
Beilstein/REAXYS Number:
1941550
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

packaging

ampule of 10 × 1.2 mL

manufacturer/tradename

Cerilliant®

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

application(s)

forensics and toxicology

format

neat

storage temp.

−20°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

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vibrant-m

M-132

MSTFA Reagent

format

neat

format

-

format

-

format

-

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

grade

analytical standard

grade

for GC derivatization

grade

for GC derivatization, synthesis grade

grade

-

vapor density

>1 (vs air)

vapor density

>1 (vs air)

vapor density

>1 (vs air)

vapor density

-

vapor pressure

8.8 mmHg ( 27 °C)

vapor pressure

8.8 mmHg ( 27 °C)

vapor pressure

8.8 mmHg ( 27 °C)

vapor pressure

-

General description

MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.

Application

MSTFA reagent may be used as a derivatizing agent in the following:
  • Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2), and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
  • Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).

Features and Benefits

  • Very volatile of TMS-acetamides.
  • More volatile than BSA or BSTFA but with similar silylation strength.
  • Useful in the analysis of volatile trace materials.
  • Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup


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The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography?mass spectrometry based metabolomics
Khakimov B, et al.
Analytical and Bioanalytical Chemistry, 405(3), 9193-9205 (2013)
Analysis of trenbolone acetate metabolites and melengestrol in environmental matrices using gas chromatography--tandem mass spectrometry
Parker AJ, et al.
Talanta, 99(3), 238-246 (2012)
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry
Sebok A, et al.
Talanta, 76(3), 642-650 (2008)
John A Bowden et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3237-3242 (2009-08-21)
Steroid derivatization was investigated by varying the experimental parameters (reagent, reaction time, and reaction temperature) to determine the optimal conditions for individual steroids, and for larger subsets. Three methods of derivatization enhancement were also investigated: the use of sonication, the
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives

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