07-892
Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody
Upstate®, from rabbit
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Synonym(s):
PTK2B, Proline-rich tyrosine kinase 2, Focal adhesion kinase 2, FADK2, Cell adhesion kinase beta, RAFTK, Calcium-dependent tyrosine kinase, CADTK
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr402)
Gene Information
human ... PTK2B(2185)
Specificity
Pyk2 phosphorylated on tyrosine residue 402
Immunogen
Peptide corresponding to amino acid region encompassing the human and rat phospho-Pyk2/CAKβ/FAK2 (Tyr402).
Application
Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Pyk2 (Tyr402) in RIPA lysate of Pyk2 transfected CEF cells
This Anti-phospho-Pyk2/CAKβ/FAK2 (Tyr402) Antibody is validated for use in WB, IC for the detection of phospho-Pyk2/CAKβ/FAK2 (Tyr402).
Quality
Routinely evaluated by immunoblot.
Target description
115 kDa
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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M D Schaller et al.
The Journal of biological chemistry, 272(40), 25319-25325 (1997-10-06)
pp125(FAK) and CAKbeta/Pyk2/CadTK/RAFTK are related protein-tyrosine kinases. It is therefore of interest whether CAKbeta shares some of the properties of pp125(FAK). Using recombinant glutathione S-transferase fusion proteins, we show that the C-terminal domains of both proteins bind paxillin in vitro.
Monika Raab et al.
Nature communications, 8, 16001-16001 (2017-07-13)
Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell
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