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14-679-M

Sigma-Aldrich

HIPK1 Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555. For use in Kinase Assays.

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eCl@ss:
32160405
NACRES:
NA.32

biological source

human

Quality Level

100
300

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 49.6 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

UniProt accession no.

Gene Information

human ... HIPK1(204851)

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14-623-M14-684-M14-656-M
Sigma-Aldrich

14-679-M

HIPK1 Protein, active, 10 µg

HIPK2 Protein, active, 10 µg Active, N-terminal His6-tagged, recombinant, human HIPK2, amino acids 165-564, for use in Kinase Assays.

14-623-M

HIPK2 Protein, active, 10 µg

Sigma-Aldrich

14-684-M

IRAK1 Protein, active, 10 µg

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

biological source

human

biological source

human

biological source

human

biological source

human

mol wt

Mw 49.6 kDa

mol wt

Mw 49.6 kDa

mol wt

Mw 59.7 kDa

mol wt

Mw 41.2 kDa

UniProt accession no.

Q86Z02

UniProt accession no.

Q9H2X6

UniProt accession no.

P51617

UniProt accession no.

P53667

Gene Information

human ... HIPK1(204851)

Gene Information

human ... HIPK2(28996)

Gene Information

-

Gene Information

human ... LIMK1(3984)

General description

N-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555.
Product Source: HIPK1 expressed by baculovirus in Sf21 cells.

Application

Research Category
Metabolism
Research Sub Category
Obesity

Metabolic Disorders

Biochem/physiol Actions

Protein Target: HIPK1
Target Sub-Family: CMGC

Quality

routinely evaluated by phosphorylation of MBP (13-104).

Physical form

Ni2+/NTA-agarose

Storage and Stability

6 months at -70°C from date of shipment

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Jae J Song et al.
The Journal of biological chemistry, 278(47), 47245-47252 (2003-09-12)
Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the nucleus to the cytoplasm, and apoptosis signal-regulating kinase 1 (ASK1) oligomerization in human prostate adenocarcinoma DU-145 cells. However, SB203580, a p38 inhibitor, did not prevent
Jeffrey A Ecsedy et al.
Molecular and cellular biology, 23(3), 950-960 (2003-01-17)
We describe an interaction between homeodomain-interacting protein kinase 1 (HIPK1) and Daxx, two transcriptional regulators important in transducing growth-regulatory signals. We demonstrate that HIPK1 is ubiquitously expressed in mice and humans and localizes predominantly to the nucleus. Daxx normally resides
Y H Kim et al.
The Journal of biological chemistry, 273(40), 25875-25879 (1998-09-25)
A novel family of cofactors that differentially interact with homeoproteins have been identified via a yeast two-hybrid screen. The proteins contain a conserved protein kinase domain that is separated from a domain that interacts with homeoproteins and hence are termed

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