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Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate

purified antibody, clone 23A8, from mouse

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Synonym(s):
Cell migration-inducing gene 5 protein, Ras-like protein TC25, migration-inducing gene 5, migration-inducing protein 5, ras-related C3 botulinum toxin substrate 1, ras-related C3 botulinum toxin substrate 1 (rho family,small GTP binding protein Rac1), ra
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

23A8, monoclonal

species reactivity

human, rat, mouse

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... RAC1(5879)

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This Item
05-389-AF64705-389-AF48809-271
vibrant-m

09-271

Anti-Rac1b Antibody

clone

23A8, monoclonal

clone

23A8, monoclonal

clone

23A8, monoclonal

clone

polyclonal

species reactivity

human, rat, mouse

species reactivity

mouse, rat, human

species reactivity

rat, mouse, human

species reactivity

mouse, human

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

affinity purified immunoglobulin

Gene Information

human ... RAC1(5879)

Gene Information

human ... RAC1(5879)

Gene Information

human ... RAC1(5879)

Gene Information

human ... RAC1(5879)

UniProt accession no.

P63000

UniProt accession no.

P63000

UniProt accession no.

P63000

UniProt accession no.

P63000

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General description

Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.

Specificity

Other species have not been tested.
Recognizes human Rac1.

Application

Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate detects level of Rac1 & has been published & validated for use in WB & IP.

Target description

21 kDa

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt. DO NOT FREEZE! Wash the magnetic beads with an appropriate buffer prior to use to remove sodium azide.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2


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Mian Zhou et al.
Cellular & molecular immunology, 20(1), 80-93 (2022-12-06)
In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern that causes inflammation. However, whether eCIRP regulates macrophage bacterial phagocytosis is unknown. Here, we reported that
Armin Bayati et al.
Cell reports, 40(3), 111102-111102 (2022-07-21)
The nervous system spread of alpha-synuclein fibrils is thought to cause Parkinson's disease (PD) and other synucleinopathies; however, the mechanisms underlying internalization and cellular spread are enigmatic. Here, we use confocal and superresolution microscopy, subcellular fractionation, and electron microscopy (EM)
Zihang Chen et al.
The Journal of physiology, 598(12), 2415-2430 (2020-04-03)
Spinal cord dorsal horn srGAP3 (slit-robo GTPase activating protein 3) increases in the initiation phase of neuropathic pain and decreases in the maintenance phase. However, Rac1 activity, which can be reduced by srGAP3, decreases in the initiation phase and increases

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