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PARP Inhibitor III, DPQ

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

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Synonym(s):
PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
Empirical Formula (Hill Notation):
C18H26N2O2
CAS Number:
Molecular Weight:
302.41
MDL number:

Quality Level

assay

≥90% (HPLC)

form

solid

potency

40 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)

InChI key

RVOUDNBEIXGHJY-UHFFFAOYSA-N

General description

A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Other Notes

Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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