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341482

Sigma-Aldrich

Ferritin, Human Liver

Ferritin, Human Liver, CAS 9007-73-2, is a native, sterile-filtered ferritin that is suitable for use in immunoassays, as an immunogen, and in enzyme/radiolabeling.

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Synonym(s):
Ferritin, Human Liver
CAS Number:
MDL number:

biological source

human

Quality Level

assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

do not freeze

technique(s)

enzyme immunoassay: suitable

impurities

Antibodies to HIV1, HIV2, Hepatitis B, Hepatitis C, tested negative (by certified tests)

solubility

water: soluble

suitability

suitable for immunoassay

Protein ID accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

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T4132F7879F4503
vibrant-m

341482

Ferritin, Human Liver

vibrant-m

T4132

holo-Transferrin human

vibrant-m

F4503

Ferritin from equine spleen

assay

≥95% (SDS-PAGE)

assay

≥98%

assay

-

assay

-

biological source

human

biological source

human

biological source

horse spleen

biological source

-

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

form

liquid

form

powder

form

liquid

form

saline solution

Gene Information

human ... FTH1(2495), FTL(2512)

Gene Information

human ... TF(7018)

Gene Information

horse ... FTL(100051593)

Gene Information

-

General description

Research area: Cell signaling

Ferritin is a major iron storage protein. It exists in a two functionally and genetically different subunits namely, the acidic, heavy or H-chain and the basic, light or L-chain. Native ferritin from human liver. Sterile-filtered.

Application

Ferritin is suitable for use in immunofluorescence assay, immunoassays, as an immunogen, and in enzyme/radiolabeling.

Biochem/physiol Actions

Ferritin is a crucial protein that has multiple functions in iron metabolism and immune regulation. It helps in maintaining the iron balance. H-ferritin is involved in various processes such as regulating immune function, hematopoiesis, hepatocyte apoptosis, and cell differentiation. Additionally, ferritin can act as a proinflammatory cytokine through protein kinase C-zeta (PKC-ζ) and nuclear factor kappa B (NFκB) signaling pathways in certain cells.(1) Ferritin serves as both an immune-suppressor and a signaling molecule, contributing to the regulation of lymphoid and myeloid cell proliferation.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 0.9% NaCl, 0.1% NaN₃, pH 7.0.

Other Notes

Addison, J.M., et al. 1983. FEBS Lett.164, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity
Recalcati S, et al.
Journal of Autoimmunity, 30(1-2), 84-89 (2008)
New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity
Recalcati S, et al.
Journal of Autoimmunity, 30(1-2), 84-89 (2008)
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells
Ruddell RG, et al.
Journal of Separation Science, 49(3), 887-900 (2009)
Ferritin, iron homeostasis, and oxidative damage
Arosio P and Levi S
Free radical biology & medicine, 33(4), 457-463 (2002)
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells
Ruddell RG, et al.
Hepatology, 49(3), 887-900 (2009)

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