MilliporeSigma
All Photos(1)

5.00112

SAFC

Cocarboxylase chloride

thiamine diphosphoric acid ester chloride EMPROVE® API

Synonym(s):
Cocarboxylase chloride, Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
CAS Number:
Molecular Weight:
460.77
MDL number:
EC Index Number:
205-836-1

Quality Level

product line

EMPROVE® API

form

solid

pH

1.0-1.4 (20 °C, 100 g/L in H2O)

mp

240-244 °C (decomposition)

solubility

220 g/L

bulk density

500 kg/m3

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

InChI

1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H

InChI key

YXVCLPJQTZXJLH-UHFFFAOYSA-N

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PHL89896C4382PHR1226
Cocarboxylase chloride thiamine diphosphoric acid ester chloride EMPROVE® API

SAFC

5.00112

Cocarboxylase chloride

Chelerythrine chloride phyproof® Reference Substance

PHL89896

Chelerythrine chloride

Cetylpyridinum chloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1226

Cetylpyridinum chloride

form

solid

form

-

form

crystalline

form

-

solubility

220 g/L

solubility

-

solubility

H2O: 1 g/mL, ethanol: 20 mg/mL

solubility

-

storage temp.

2-25°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

Quality Level

600

Quality Level

-

Quality Level

100

Quality Level

300

product line

EMPROVE® API

product line

phyproof® Reference Substance

product line

-

product line

-

pH

1.0-1.4 (20 °C, 100 g/L in H2O)

pH

-

pH

-

pH

-

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase chloride Emprove® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Chloride (thiamine diphosphoric acid ester chloride) Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Elemental Impurities Information

Available by subscription or for a fee

API Information Package

Available by subscription or for a fee

Learn more about the benefits an Emprove® Program subscription can provide
Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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