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516481-M

Sigma-Aldrich

Pepstatin A, Synthetic

Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.

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Synonym(s):
Pepstatin A, Synthetic, Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
Empirical Formula (Hill Notation):
C34H63N5O9
CAS Number:
Molecular Weight:
685.89
MDL number:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

solid

optical activity

[α]20.0/D -90.0±5.0, c = 0.5 in methanol

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL
methanol: 1 mg/mL

storage temp.

2-8°C

InChI

1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1

InChI key

FAXGPCHRFPCXOO-JHTFMCFMSA-N

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This Item
PEPS-RO110175-M516483
vibrant-m

516481-M

Pepstatin A, Synthetic

vibrant-m

PEPS-RO

Pepstatin

vibrant-m

110175-M

Acetyl-Pepstatin

vibrant-m

516483

Pepstatin A, Penetratin

form

solid

form

lyophilized

form

solid

form

lyophilized solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Roche

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze

storage condition

-

storage condition

OK to freeze

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

General description

A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
Effective concentration: 1.0 µM.

Biochem/physiol Actions

EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
Primary Target
cathepsin D

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.
Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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