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584223

Sigma-Aldrich

Tetrahydrouridine

InSolution, ≥90%, competitive inhibitor of cytidine deaminase

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Synonym(s):
InSolution Tetrahydrouridine, THU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
Empirical Formula (Hill Notation):
C9H16N2O6 · 2H2O
CAS Number:
Molecular Weight:
284.26
MDL number:

Quality Level

assay

≥90% (TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

shipped in

dry ice

storage temp.

−70°C

SMILES string

OC1CCN([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C(N1)=O

InChI

1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1

InChI key

UCKYOOZPSJFJIZ-XVKVHKPRSA-N

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This Item
584222586006565794
Tetrahydrouridine InSolution, ≥90%, competitive inhibitor of cytidine deaminase

584223

Tetrahydrouridine

Tetrahydrouridine Potent competitive inhibitor of cytidine deaminase. Also available as a 100 mM solution in H2O.

584222

Tetrahydrouridine

Thapsigargin InSolution, ≥97%, tumor-promoting sesquiterpene lactone

586006

Thapsigargin

β-Secretase Inhibitor IV InSolution, ≥95%

565794

β-Secretase Inhibitor IV

assay

≥90% (TLC)

assay

≥90% (TLC)

assay

≥97% (TLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−70°C

storage condition

OK to freeze, protect from light, avoid repeated freeze/thaw cycles

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

General description

A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cytidine deaminase
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Other Notes

Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486.

Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem.267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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