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AB1583

Sigma-Aldrich

Anti-Neuropeptide Y Antibody

serum, Chemicon®

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Synonym(s):
NPY
eCl@ss:
32160702
NACRES:
NA.41

biological source

sheep

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

invertebrates, rabbit, guinea pig

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
radioimmunoassay: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

rabbit ... Npy(100301542)

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N9528AB1529AB1581
Sigma-Aldrich

AB1583

Anti-Neuropeptide Y Antibody

biological source

sheep

biological source

rabbit

biological source

sheep

biological source

sheep

antibody form

serum

antibody form

whole antiserum

antibody form

serum

antibody form

serum

species reactivity

invertebrates, rabbit, guinea pig

species reactivity

rat, sheep, pig, human

species reactivity

rabbit, rat, guinea pig

species reactivity

guinea pig, rabbit, rat

Gene Information

rabbit ... Npy(100301542)

Gene Information

rat ... Npy(24604)

Gene Information

guinea pig ... Nos1(100729682)
rabbit ... Nos1(100009243)
rat ... Nos1(24598)

Gene Information

guinea pig ... Vip(100735454)
rat ... Vip(117064)

UniProt accession no.

P01303

UniProt accession no.

P01303

UniProt accession no.

P29475

UniProt accession no.

P01282

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Specificity

Neuropeptide Y (NPY). The specificity was determined by RIA. Synthetic peptides somatostatin-14, leu-enkephalin, met-enkephalin, oxytocin, Agr8-vasopressin, vasoactive intestinal peptide and angiotensin II showed less than 0.005% cross reactivity and substance P less than 0.02%. Peptide YY and bovine pancreatic polypeptide showed approximately 36% and 0.05% cross reactivity respectively. Human Peptide YY shares 65% homology amino acid sequence for human NPY.



Synthetic NPY completely abolishes radio labeled NPY binding to NPY antibody in RIA and antibody binding to tissue antigen.

Immunogen

Synthetic NPY peptide conjugated to bovine thyroglobulin.

Application

Detect Neuropeptide Y using this Anti-Neuropeptide Y Antibody validated for use in IH, RIA.
Immunohistochemistry: 1:5,000 on rabbit and guinea pig using an ABC detection method.

RIA

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
CNS Control of Metabolism

Hormones & Receptors

Physical form

Sheep serum. Lyophilized, no preservatives. Reconstitute with 100 μL of sterile distilled water.

Storage and Stability

Maintain at -20 to -70°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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David J Cox et al.
The Journal of comparative neurology, 509(6), 551-565 (2008-06-12)
Noradrenaline (NA) acting via beta-adrenergic receptors (betaARs) plays an important role in the modulation of memory in the hippocampus. betaARs have been shown to be expressed in principal cells, but their distribution across different interneuron classes is unknown. We have
Alexander V Loktev et al.
Cell reports, 5(5), 1316-1329 (2013-12-10)
Human monogenic obesity syndromes, including Bardet-Biedl syndrome (BBS), implicate neuronal primary cilia in regulation of energy homeostasis. Cilia in hypothalamic neurons have been hypothesized to sense and regulate systemic energy status, but the molecular mechanism of this signaling remains unknown.
Darren Cameron et al.
Pain, 156(10), 2061-2071 (2015-06-24)
The anterolateral tract (ALT), which originates from neurons in lamina I and the deep dorsal horn, represents a major ascending output through which nociceptive information is transmitted to brain areas involved in pain perception. Although there is detailed quantitative information
Enhanced neuropeptide Y immunoreactivity and vasoconstriction in mesenteric small arteries from spontaneously hypertensive rats.
Kathryn A Gradin, Jia-Yi Li, Ove Andersson, Ulf Simonsen
Journal of Vascular Research null
Andrea V Rozo et al.
Molecular metabolism, 6(7), 748-759 (2017-07-14)
Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor

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