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AB2256

Sigma-Aldrich

Anti-GABA B Receptor R1 Antibody

serum, from guinea pig

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Synonym(s):
GABA-B receptor, GABA-B receptor 1, GABAB, subunit 1c, gamma-aminobutyric acid (GABA) B receptor 1, gamma-aminobutyric acid B receptor 1, seven transmembrane helix receptor
eCl@ss:
32160702
NACRES:
NA.41

biological source

guinea pig

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Gabbr1(54393)

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This Item
AB2255AB15415SAB4501063
Anti-GABA B Receptor R1 Antibody serum, from guinea pig

AB2256

Anti-GABA B Receptor R1 Antibody

Anti-GABA B Receptor R2 Antibody serum, from guinea pig

AB2255

Anti-GABA B Receptor R2 Antibody

Sigma-Aldrich

AB15415

Anti-GABARAP Antibody

antibody form

serum

antibody form

serum

antibody form

serum

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

species reactivity

mouse, human, rat

species reactivity

rhesus macaque, rat

species reactivity

human, rat

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

ELISA: 1:1000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

Gene Information

mouse ... Gabbr1(54393)

Gene Information

human ... GABBR2(9568)

Gene Information

human ... GABARAP(11337)

Gene Information

human ... GABBR1(2550)

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General description

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Specificity

Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1)
Reactivity with other species has not been determined.

Immunogen

Epitope: C-Terminus
interaction w/ ATF4
Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK)

Application

Detect GABA B Receptor R1 using this Anti-GABA B Receptor R1 Antibody validated for use in WB, IH.
Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Quality

Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate.

Target description

~100-105 kDa

Physical form

GST-Depleted Sera with 0.05% NaN3.

Storage and Stability

Stable for 1 year at -20ºC from date of receipt.

Analysis Note

Control
Rat brain lysates

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.
Lancaster, E; Lai, M; Peng, X; Hughes, E; Constantinescu, R; Raizer, J; Friedman et al.
Lancet Neurology null
Camille Mazo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(32), 8289-8304 (2016-08-12)
Sensory perception emerges from the confluence of sensory inputs that encode the composition of external environment and top-down feedback that conveys information from higher brain centers. In olfaction, sensory input activity is initially processed in the olfactory bulb (OB), serving
Ji-Yong Kang et al.
The Journal of biological chemistry, 292(16), 6621-6632 (2017-02-19)
The behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result from imbalances in the relative strengths of excitatory and inhibitory neurotransmission. Although modified neuronal excitability is thought to be of significance, the contribution that
Matthew T Valley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14660-14665 (2013-09-13)
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic
Shigenori Inagaki et al.
Cell reports, 31(13), 107814-107814 (2020-07-02)
Sensory information is selectively or non-selectively enhanced and inhibited in the brain, but it remains unclear whether and how this occurs at the most peripheral level. Using in vivo calcium imaging of mouse olfactory bulb and olfactory epithelium in wild-type and

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