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AB5702

Sigma-Aldrich

Anti-HES-1 Antibody

Chemicon®, from rabbit

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Synonym(s):
Hairy 1
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rodent, human, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... HES1(3280)
mouse ... Hes1(15205)

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This Item
ABN1386WH0003280M1AV32512
vibrant-m

AB5702

Anti-HES-1 Antibody

vibrant-m

ABN1386

Anti-HES-1 Antibody

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

UniProt accession no.

Q14469

UniProt accession no.

P35428

UniProt accession no.

Q14469

UniProt accession no.

Q9Y5J3

clone

polyclonal

clone

polyclonal

clone

4D9, monoclonal

clone

polyclonal

species reactivity

rodent, human, mouse

species reactivity

mouse

species reactivity

human

species reactivity

human

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General description

Hes1 is a transcriptional repressor of genes that require a bHLH protein for their transcription. It may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 is expressed in developing neuroectodermal and endodermal endocrine tissues, and Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia.

Specificity

Reactivity with other species has not been confirmed.
Recognizes HES-1 (Hairy family), a Helix-loop-helix class of transcription factor.

Immunogen

Synthetic peptide.

Application

Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Neuronal & Glial Markers
This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.
Western Blot:
1:200-1:1,000 dilution using ECL.

Immunohistochemistry:
1:200-1:1,000 dilution of a previous lot worked.

Optimal working dilutions must be determined by the end user.

Target description

29 kDa

Physical form

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Storage and Stability

Stable for 1 year at -80ºC from date of receipt.

Analysis Note

Control
Human neural stem cells, Raji cell lysate.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Notch signaling in descending thoracic aortic aneurysm and dissection.
Zou, S; Ren, P; Nguyen, M; Coselli, JS; Shen, YH; LeMaire, SA
Testing null
Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation.
Ota, MS; Kaneko, Y; Kondo, K; Ogishima, S; Tanaka, H; Eto, K; Kondo, T
PLoS Genetics null
Sheheryar Kabraji et al.
Breast cancer research : BCR, 19(1), 88-88 (2017-08-03)
Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment responses are likely determined by mechanisms that enable cancer cells to resist being killed.
Rute M M Ferreira et al.
Cell reports, 21(4), 966-978 (2017-10-27)
The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on
Eva Skarmoutsou et al.
International journal of molecular medicine, 42(1), 392-404 (2018-04-06)
Forkhead box protein 3 (FOXP3) transcription factor is expressed by immune cells and several human cancers and is associated with tumor aggressiveness and unfavorable clinical outcomes. NOTCH and transforming growth factor‑β (TGF‑β) protumorigenic effects are mediated by FOXP3 expression in several

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