FCMAB288A6
Milli-Mark® Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor™647, clone Apu3
clone Apu3, Milli-Mark®, from rabbit
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.45
Recommended Products
biological source
rabbit
Quality Level
conjugate
ALEXA FLUOR™ 647
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Apu3, monoclonal
species reactivity
human
manufacturer/tradename
Milli-Mark®
technique(s)
flow cytometry: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... UBB(7314)
General description
Polyubiquitin chains linked through the Lys48 residue of ubiquitin are most commonly associated with proteins targeted for proteosomal degradation. In contrast, polyubiquitin chains linked through the Lys63 residue of ubiquitin (Ub) are associated with nonproteolytic functions such as signal transduction. Lys63-linked polyUb chains connect components of NFκB signaling in a highly regulated manner, and genetic evidence indicates the involvement of Lys63-linked Ub chains in stress response and DNA repair. Research in yeast has suggested Lys63-linked Ub chains stimulate endocytosis.
Specificity
Recognizes ubiquitin linked at Lys63. Does not recognize ubiquitin linked at Lys48 or free ubiquitin.
Immunogen
Immunogen used was di-ubiquitin linked at Lys63.
Application
This Milli-Mark Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3 is validated for use in FC for the detection of Ubiquitin.
Quality
Evaluated by flow cytometry using HeLa cells
Target description
Molecular weight varies.
Physical form
Purified recombinant rabbit monoclonal IgG1 conjugated to Alexa Fluor 647 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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