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Anti-Cav1.2 calcium channel Antibody, clone L57/46

clone L57/46, from mouse

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calcium channel, voltage-dependent, L type, alpha 1C subunit1, voltage-gated calcium channel alpha subunit Cav1.2, calcium channel, L type, alpha 1 polypeptide, isoform 1, cardic muscle, calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit,

biological source


Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies


L57/46, monoclonal

species reactivity

mouse, human

species reactivity (predicted by homology)

rabbit (based on 100% sequence homology), rat (based on 100% sequence homology)


immunohistochemistry: suitable
western blot: suitable



NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification


Gene Information

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This Item
antibody form

purified immunoglobulin

antibody form

fractionated antiserum

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin


L57/46, monoclonal






8F9.1, monoclonal

species reactivity

mouse, human

species reactivity

rat, mouse, human

species reactivity

human, mouse, rat

species reactivity



immunohistochemistry: suitable, western blot: suitable


western blot: 5-10 μg/mL using rat brain tissue lysate


immunocytochemistry: suitable, western blot: 1:200 using rat heart membranes


immunohistochemistry: suitable (paraffin), western blot: suitable









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General description

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.


This antibody recognizes Cav1.2 calcium channel at the cytoplasmic domain.


Epitope: Cytoplasmic domain
Recombinant protein corresponding to rabbit Cav1.2 calcium channel at the cytoplasmic domain proximal to the C-terminus.


Immunohistochemistry Analysis: 1:300 dilution of this antibody has been shown to detect Cav1.2 calium channel in human kidney tissue.
Research Category
Research Sub Category
Ion Channels & Transporters
This Anti-Cav1.2 calcium channel Antibody, clone L57/46 is validated for use in WB, IH for the detection of Cav1.2 calcium channel.


Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Cav1.2 calcium channel on 10 µg of mouse brain tissue lysate.

Target description

Observed at ~ 240 kDa

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Mouse brain tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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