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MAB2641

Sigma-Aldrich

Anti-Fibrillin (Pan) Antibody, clone 689

clone 689, from mouse

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Synonym(s):
EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

689, monoclonal

species reactivity

mouse

species reactivity (predicted by homology)

chicken (based on 100% sequence homology), human (based on 100% sequence homology)

technique(s)

ELISA: suitable
immunohistochemistry: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... EFEMP1(2202)

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MABS1217SAB4500863MABE1154
species reactivity

mouse

species reactivity

human

species reactivity

human, rat, mouse

species reactivity

human, rat, yeast, mouse, Drosophila

Gene Information

human ... EFEMP1(2202)

Gene Information

human ... FBLN1(2192)

Gene Information

human ... FBN1(2200)

Gene Information

human ... FBL(2091)

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

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General description

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

Specificity

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

Immunogen

Recombinant protein corresponding to human Fibrillin 3.

Application

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.
ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

Quality

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

Target description

~ 350 kDa calculated

Physical form

Format: Purified

Analysis Note

Control
Mouse skin tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Yong Yuan et al.
PloS one, 14(3), e0212569-e0212569 (2019-03-07)
Pseudoexfoliation (PEX) syndrome is an age-related systemic disease with ocular manifestations. The development of animal models is critical in order to elucidate the cause of the disease and to test potential treatment regimens. The purpose of this study is to
Tomoko Matsuzaki et al.
Journal of cellular physiology, 236(3), 1980-1995 (2020-07-31)
Fibrillins (FBNs) form mesh-like structures of microfibrils in various elastic tissues. RECK and FBN1 are co-expressed in many human tissues, suggesting a functional relationship. We found that dermal FBN1 fibers show atypical morphology in mice with reduced RECK expression (RECK-Hypo

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