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MABC60

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Anti-KiSS-1 Antibody, clone 8H4.1

clone 8H4.1, from mouse

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Synonym(s):
Metastasis-suppressor KiSS-1, Kisspeptin-1, Metastin, Kisspeptin-542, Kisspeptin-143, Kisspeptin-134, Kisspeptin-10
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

8H4.1, monoclonal

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KISS1(3814)

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This Item
WH0003814M5MABC607MABC552
antibody form

purified antibody

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified antibody

clone

8H4.1, monoclonal

clone

1F7, monoclonal

clone

15C3.2, monoclonal

clone

11C7.1, monoclonal

species reactivity

human, rat

species reactivity

human

species reactivity

monkey, human

species reactivity

human

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

isotype

IgG1κ

isotype

IgG2aκ

isotype

IgG2aκ

isotype

IgG2bκ

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General description

Metastasis-suppressor KiSS-1 (KiSS-1; or Kisspeptin-1) is one of several endogenous ligands for the orphan G-protein coupled receptor GPR54. KiSS-1 functions as a suppressor of metastasis in various types of cancers, by inhibiting migration and proliferation in affected cells. This effect may be produced by the activation of multiple signaling pathways: Ligand-bound GPR54 activates IP3 and PKC signaling via a PLC pathway; and ERK 1 and ERK 2 by a cPLA2, which may lead to increased calcium signaling and gene transcription, respectively. More recently, however, KiSS-1/GPR54 signaling has been implicated in puberty and development. KiSS-1/GPR54 may regulate signaling of GnRH neurons during puberty and may influence the release of FH and LSH hormones. KISS-1 is highly expressed in the CNS, testis, pancreas, intestine, ovary, and placenta.

Immunogen

Recombinant protein corresponding to human KiSS-1.

Application

Anti-KiSS-1 Antibody, clone 8H4.1 is an antibody against KiSS-1 for use in IHC, Western Blotting.
Immunohistochemistry Analysis: 1:1,000 dilution from a representative lot detected KiSS-1 in human pancreas and rat testis tissues.

Quality

Evaluated by Immunohistochemistry in human placenta tissue.

Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected KiSS-1 in human placenta tissue.

Target description

15 kDa calculated

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Franco Juan Cruz Dolcetti et al.
Aging, 14(21), 8615-8632 (2022-11-04)
The process of aging is the result of progressive loss of homeostasis and functional body impairment, including the central nervous system, where the hypothalamus plays a key role in regulating aging mechanisms. The consequences of aging include a chronic proinflammatory
Megan L Greenwald-Yarnell et al.
Endocrinology, 157(4), 1555-1565 (2016-02-11)
A variety of data suggest that estrogen action on kisspeptin (Kiss1)-containing arcuate nucleus neurons (which coexpress Kiss1, neurokinin B (the product of Tac2) and dynorphin (KNDy) neurons restrains reproductive onset and function, but roles for estrogen action in these Kiss1
Ting Zhang et al.
Nature, 606(7914), 594-602 (2022-05-26)
Only a small proportion of patients with cancer show lasting responses to immune checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an emerging determinant of resistance to ICB therapy and prevents ICB responsiveness by repressing immunogenic double-stranded RNAs (dsRNAs)
Yang Li et al.
PloS one, 17(6), e0259609-e0259609 (2022-06-16)
Polycystic ovary syndrome often starts in puberty, and its pathogenesis is not clear. This study aimed to explore the pathogenesis of pubertal polycystic ovary syndrome (PCOS) and assess the therapeutic effect of electroacupuncture on pubertal PCOS. Dihydrotestosterone (DHT) was used
Ting Zhang et al.
Cell, 180(6), 1115-1129 (2020-03-24)
Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-protein kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain-like pseudokinase (MLKL)-dependent necroptosis in infected cells. ZBP1 initiates RIPK3-driven cell death by sensing IAV RNA and

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