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MABN759

Sigma-Aldrich

Anti-DISC1 Antibody, clone 3D4

clone 3D4, 1 mg/mL, from mouse

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Synonym(s):
Disrupted in schizophrenia 1 protein
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3D4, monoclonal

species reactivity

human

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... DISC1(27185)

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SAB5701553PRS4293SAB2500312
Anti-DISC1 Antibody, clone 3D4 clone 3D4, 1 mg/mL, from mouse

MABN759

Anti-DISC1 Antibody, clone 3D4

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

goat

Gene Information

human ... DISC1(27185)

Gene Information

human ... DISC1(27185)

Gene Information

human ... DISC1(27185)

Gene Information

human ... DISC1(27185)

clone

3D4, monoclonal

clone

monoclonal

clone

polyclonal

clone

polyclonal

antibody form

purified immunoglobulin

antibody form

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

isotype

IgG1κ

isotype

-

isotype

-

isotype

-

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General description

Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

Immunogen

Recombinant protein corresponding to human DISC1.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DISC1 in human cerebellum and human cerebral cortex tissue.
Western Blotting Analysis: A representative lot detected DISC1 in human NLF cell lysate (Leliveld, S. R., et al. (2008). Journal of Neuroscience. 28(15):3839-3845).
Immunocytochemistry Analysis: A representative lot detected DISC1 in transfected cells (Bader, V., et al. (2012). Human Molecular Genetics. 21(20):4406-4418).
Immunohistochemistry Analysis: A representative lot detected DISC1 in human cortical tissue sections (Seshadri, S. et al. (2010). PNAS. 107(12):5622-5627).
Immunohistochemistry Analysis: A representative lot detected DISC1 in human brain tissue (Bader, V., et al. (2012). Human Molecular Genetics. 21(20):4406-4418).
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-DISC1 Antibody, clone 3D4 is validated for use in IHC (Paraffin), western blotting andICC for the detection of DISC1.

Quality

Evaluated by Immunohistochemistry in human cerebral cortex tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected DISC1 in human cerebral cortex tissue.

Target description

94 kDa calculated

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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