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MABS2044

Sigma-Aldrich

Anti-HPd2 Antibody, clone DHIC3-5H10

clone DHIC3-5H10, from mouse

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Synonym(s):
Human pancreatics duct cells
eCl@ss:
32160702

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DHIC3-5H10, monoclonal

species reactivity

human

packaging

antibody small pack of 25 μg

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)

isotype

IgMκ

target post-translational modification

unmodified

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This Item
MABS2040MABS2045MABS1998
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

purified immunoglobulin

clone

DHIC3-5H10, monoclonal

clone

DHIC5-4D9, monoclonal

clone

DHIC2-2B4, monoclonal

clone

HIC3-2D12, monoclonal

isotype

IgMκ

isotype

IgMκ

isotype

IgG1λ

isotype

IgMκ

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable (paraffin)

technique(s)

immunohistochemistry: suitable (paraffin)

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable (paraffin)

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable (paraffin)

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General description

Pancreas performs both the endocrine and the exocrine function. The bulk of pancreas is composed of exocrine cells that produce digestion enzymes which are released into ducts to be emptied into the duodenum. The endocrine pancreas is composed of islets of Langerhans that produce hormones. At least five distinct endocrine cell types have been identified in the endocrine pancreas, each producing a different hormone. Beta cells produce insulin, which is considered as an anabolic hormone and regulates blood glucose levels and is also involved in fat and protein synthesis. Alpha cells produce glucagon that acts when blood glucose levels are low. Ductal cells of pancreas form the epithelial lining of the branched tubes that deliver digestive enzymes into the duodenum. They also secrete bicarbonate to neutralize acidic contents coming in from stomach. Duct cells may contribute up to 10% of all pancreatic cells. Acinar cells function as a unit of the exocrine pancreas and they synthesize, store, and secrete digestive enzymes (lipase, alpha amylase, trypsin, and chymotrypsin), which under normal physiological conditions are activated only after reaching the duodenum. Premature activation of these enzymes within pancreatic acinar cells can lead to acute pancreatitis. Clone DCHI3-5H10 can be used to detect duct cells in human pancreatic tissue. (Ref.: Dorrell, C., et al. (2008). Stem Cell Research (2008). 1(3); 183-194; Grapin-Botton, A (2005). Int. J. Biochem. Cell Biol. 37(3); 504-510; Leung, PS (2006). Int. J. Biochem. Cell Biol. 38(7); 1024-1030).

Specificity

Clone DCHI3-5H10 specifically detects human pancreatic duct cells.

Immunogen

Trypsin-dissociated human pancreatic duct cells.

Application

Anti-HPd2, clone DHIC3-5H10, Cat. No. MABS2044, is a mouse monoclonal antibody that detects Duct2 cells of pancreas and has been tested for use in Immunofluorescence and Immunohistochemistry (Paraffin).
Immunofluorescence Analysis: A representative lot detected HPd2 in Immunofluorescence applications (Dorrell, C., et. al. (2008). Stem Cell Res. 1(3):183-94).
Research Category
Signaling

Quality

Evaluated by Immunohistochemistry (Paraffin) in human pancreatic tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected HPd2 in human pancreatic tissue sections.

Physical form

Format: Purified
Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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