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Key Documents

MABT908

Sigma-Aldrich

Anti-Integrin beta-8 Antibody, clone 6B9

clone 6B9, from mouse

Synonym(s):

ITGB8

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6B9, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

ambient

target post-translational modification

unmodified

Gene Information

human ... ITGB8(3696)

General description

Integrin beta-8 (UniProt: P26012) is encoded by the ITGB8 gene (Gene ID: 3696) in human. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. The integrin receptors are composed of alpha and beta subunits and each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Integrin beta-8 is a single-pass type I membrane protein that associates with alpha V chain in a non-covalent manner to make a heterodimer that serves as a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Integrin beta-8 binding to LAP is reported to promote the proteolytic release of active TGF-beta from LAP. Integrin beta-8 contains a VWFA domain and four cysteine-rich repeats. It is required for vascular morphogenesis in the embryonic brain and yolk sac. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells. Higher expression of ITGB8 is linked to high angiogenic and poorly invasive glioblastoma tumors. Conversely, low expression of ITGB8 correlates with highly invasive, but low angiogenic tumors. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells.

Specificity

Clone 6B9 detects human integrin beta-8 subunit.

Immunogen

A truncated recombinant form of human Integrin B8 corresponding to first 682 amino acids.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin beta-8 in human colon and human placenta tissues.
Research Category
Cell Structure
This mouse monoclonal Anti-Integrin beta-8 Antibody, clone 6B9, Cat. No. MABT908, is tested for use in Immunohistochemistry (Paraffin) for the detection of Integrin beta-8.

Quality

Evaluated by Immunohistochemistry in human colon tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Integrin beta-8 in human colon tissue.

Target description

85.63 kDa calculated.

Physical form

Format: Purified
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1


Certificates of Analysis (COA)

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