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MPC4NTR10

Millipore

Multiscreen® 96 well Plate, polycarbonate membrane

pore size 0.4 μm, non-sterile

Synonym(s):

96-Well Plate

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About This Item

UNSPSC Code:
41104923
eCl@ss:
32039006
NACRES:
NB.22

material

flat bottom wells
polycarbonate membrane
polystyrene

Quality Level

description

This 96-well filter plate has a Polycarbonate membrane used for Permeability studies.

sterility

non-sterile

product line

MultiScreen®

feature

lid

manufacturer/tradename

MultiScreen®

parameter

100 μL sample volume (per well)

technique(s)

DNA purification: suitable
activity assay: suitable (with precipitations)
ligand binding assay: suitable
parallel artificial membrane permeation assay (PAMPA): suitable
receptor binding assay: suitable

plate size

96 wells

well maximum volume

300 μL

working volume

125 μL

pore size

0.4 μm pore size

application(s)

sample preparation

shipped in

ambient

General description

Filter Code: PCF
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput

Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1

PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3

MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.

Application

Research Category
Assays

Protein

Physical form

Color Code: Clear

Other Notes

Automation Compatible: No

Legal Information

MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Articles

This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.

This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes

Combining solubility & PAMPA assays streamlines drug permeability testing.

Protocols

Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.

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