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34044

Supelco

Tiamulin

VETRANAL®, analytical standard

Synonym(s):

(1S,2R,3S,4S,6R,7S,14R)-6-[(2-Diethylaminoethylthio)acetoxy]-3-hydroxy-2,4,7,14-tetramethyl-4-vinyltricyclo[5,4,3,01.8]tetradecan-9-one

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About This Item

Empirical Formula (Hill Notation):
C28H47NO4S
CAS Number:
Molecular Weight:
493.74
EC Number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

mode of action

enzyme | inhibits

Storage temp.

2-8°C

SMILES string

CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)C1(C)[C@@H]2C(=O)CC3

InChI

1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1

Inchi Key

UURAUHCOJAIIRQ-QGLSALSOSA-N

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General description

Chemical structure: macrolide
Tiamulinis a veterinary drug with very low water solubility (0.000524 mg/mL). Its mode of action involves suppressing protein synthesis in bacteria.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
For detailed application information, please see the Frequently Asked Questions (FAQ) section at the bottom of this page.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

hcodes

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)


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"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin?
Schlunzen F, et al.
Molecular Microbiology, 54(05), 1287-1294 (2004)
Petra Reinhold et al.
Veterinary journal (London, England : 1997), 187(3), 405-407 (2010-08-31)
The effect of short-term antimicrobial treatment on natural excretion of Chlamydia suis in rectal swabs and C. suis and Chlamydophila psittaci in nasal swabs was investigated in 47 clinically normal piglets by quantitative real-time PCR. Pigs were treated IM with
K M S Islam et al.
Poultry science, 88(11), 2353-2359 (2009-10-17)
Tiamulin hydrogen fumarate is a semisynthetic derivative of the diterpene antibiotic pleuromutilin used in poultry medicine to treat mainly Mycoplasma- and Brachyspira-related diseases. Its use over 30 yr has not generally increased the development of resistance to these pathogens but
T F Duinhof et al.
Tijdschrift voor diergeneeskunde, 133(14-15), 604-608 (2008-09-05)
This case study describes the isolation ofa multiresistant strain ofBrachyspira hyodysenteriae in April 2007 in a Dutch sow herd with recurrent diarrhoea. Examination of faecal samples taken from 7-month-old breeding gilts with diarrhoea revealed the presence of resistance against tiamulin
K M S Islam et al.
Poultry science, 87(12), 2528-2534 (2008-11-29)
In an earlier study, the continuous medication of broiler feed with a combination of tiamulin (TIA; 20 mg/kg), chlortetracycline (CTC; 60 mg/kg), and the ionophore anticoccidial salinomycin (SAL; 60 mg/kg) caused an initial increase in BW and feed efficiency (FE;

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