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34093

Supelco

Closantel

PESTANAL®, analytical standard

Synonym(s):

5′-Chloro-4′-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2′-methylsalicylanilide, N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide

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About This Item

Empirical Formula (Hill Notation):
C22H14Cl2I2N2O2
CAS Number:
Molecular Weight:
663.07
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

storage temp.

2-8°C

SMILES string

Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c3cc(I)cc(I)c3O

InChI

1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)

InChI key

JMPFSEBWVLAJKM-UHFFFAOYSA-N

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General description

Closantel belongs to the salicylanilide class of anthelmintics, that can extensively bind to the plasma albumin. It can be effectively used against, a vast range of blood feeding internal parasites.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificates of Analysis (COA)

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Quantitative determination of Closantel residues in milk by high-performance liquid chromatography with fluorescence detection
Stove.G, et al.
Journal of Chromatography A, 846, 383-386 (1999)
Yumi Kumagai et al.
Infection and immunity, 74(9), 5014-5022 (2006-08-24)
Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, replicates in early endosomes by avoiding lysosomal fusion in monocytes and macrophages. In E. chaffeensis we predicted three pairs of putative two-component regulatory systems (TCSs) designated PleC-PleD, NtrY-NtrX, and CckA-CtrA based
Closantel toxicosis in kid goats.
R Ecco et al.
The Veterinary record, 159(17), 564-566 (2006-10-24)
R E B Hanna et al.
Veterinary parasitology, 142(1-2), 78-90 (2006-08-12)
Sixteen calves approximately 6 months old were each infected with 500 metacercariae of Fasciola hepatica. Thirty-two days later they were weighed and divided into two groups, and on day 35 all calves in one of the groups were injected subcutaneously
Haemonchus contortus: the uptake and metabolism of closantel
Rothwell J and Sangster N
International Journal For Parasitology, 27, 313-319 (1997)

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