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61188

Supelco

Losartan potassium

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Synonym(s):
2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
Empirical Formula (Hill Notation):
C22H22ClKN6O
CAS Number:
Molecular Weight:
461.00
Beilstein:
5845770
MDL number:
PubChem Substance ID:
NACRES:
NA.24

form

powder or crystals

Quality Level

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

SMILES string

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChI key

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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This Item
1370462BP867Y0001062
Losartan potassium

Supelco

61188

Losartan potassium

Losartan potassium United States Pharmacopeia (USP) Reference Standard

USP

1370462

Losartan potassium

Losartan potassium British Pharmacopoeia (BP) Reference Standard

BP867

Losartan potassium

Losartan potassium European Pharmacopoeia (EP) Reference Standard

Y0001062

Losartan potassium

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

impurities

≤0.5% water

impurities

-

impurities

-

impurities

-

General description

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.
Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.

Application

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques.
  • Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T1503
Product Number
-
25G
Pack Size/Quantity

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Sigma-Aldrich

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Sigma-Aldrich

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USP

USP

1370484

Losartan Related Compound B

Angiotensin II human ≥93% (HPLC), powder

Sigma-Aldrich

A9525

Angiotensin II human

Eprosartan mesylate ≥98% (HPLC)

Sigma-Aldrich

E2535

Eprosartan mesylate

Losartan Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1370473

Losartan Related Compound A

vibrant-m

C2174000

Cilazapril

Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
Carlucci G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 23(1), 185-189 (2000)
Christopher J Haddock et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(6), R1027-R1035 (2020-04-16)
There are examples of physiological conditions under which thirst is inappropriately exaggerated, and the mechanisms for these paradoxical ingestive behaviors remain unknown. We are interested in thirst mechanisms across the female life cycle and have identified a novel mechanism through
Michael D Kim et al.
ERJ open research, 7(1) (2021-02-04)
The aim was to determine whether losartan reduces cigarette smoke (CS)-induced airway inflammation and mucus hypersecretion in an in vitro model and a small clinical trial. Primary human bronchial epithelial cells (HBECs) were differentiated at the air-liquid interface (ALI) and
Validated RP-HPLC method for simultaneous quantitation of losartan potassium and metolazone in bulk drug and formulation.
Dubey R, et al.
Scientia Pharmaceutica, 79(3), 545-554 (2011)
LC/MS/MS method for the simultaneous estimation of losartan potassium and irbesartan in rat plasma
Prasad BGSVS, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 1(The), 206-215 (2009)

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